منابع مشابه
Antitumour immune responses.
The role of the immune system in combating tumour progression has been studied extensively. The two branches of the immune response - humoral and cell-mediated - act both independently and in concert to combat tumour progression, the success of which depends on the immunogenicity of the tumour cells. The immune system discriminates between transformed cells and normal cells by virtue of the pre...
متن کاملTin-based Antitumour Drugs
We have been active in the synthesis and characterization of tin-based antitumour compounds for several years and we would like to summarize here the results that have already been patented(1) and that may therefore be disclosed(2). We synthesized some diorganotin 2,6-pyridinedicarboxylates.The dimethyltin compound has been found inactive in vitro, whereas the di-n-butyltin, di-t-butyltin and d...
متن کاملPentamethylcarboxylate Ruthenocene Based Antitumour Agent
Background: Unlike iron ruthenium is not an essential element for life. However, the behavior of ruthenium compounds in biological systems and, in particular their use as antitumour agents has attracted much attention recently. This study aims to determine antitumour properties against human tumour cell line HeLa of pentamethylcarboxylate ruthenocene. Methods: This is an in vitro study by apply...
متن کاملThe antitumour activities of statins
Richard J. Ablin, PhD, Research Professor of Immunobiology, University of Arizona College of Medicine and the Arizona Cancer Center, Tucson, Arizona, U.S.A., and Phil Gold, PhD MD, Professor of Medicine, Physiology, and Oncology, McGill University, Montreal, Quebec, Canada, Section Editors. Abnormally elevated levels of serum cholesterol have been demonstrated to contribute to atherosclerosis a...
متن کاملDiethylpyrocarbonate and permanganate provide evidence for an unusual DNA conformation induced by binding of the antitumour antibiotics bleomycin and phleomycin.
DNA structural changes induced by bleomycin have been investigated using diethylpyrocarbonate and permanganate as probes under conditions in which the antibiotic binds to, but does not cut the DNA. Diethyl-pyrocarbonate shows an enhanced reaction with adenines in the presence of the antibiotic in the sequences GTA greater than GCA greater than GAA, on the 3' side of the drug cutting site (GPy)....
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ژورنال
عنوان ژورنال: British Journal of Cancer
سال: 1979
ISSN: 0007-0920,1532-1827
DOI: 10.1038/bjc.1979.87